Response Heterogeneity to Lifestyle Intervention among Latino Adolescents

Autor/inn/en	Peña, Armando; McNeish, Daniel; Ayers, Stephanie L.; Olson, Micah L.; Vander Wyst, Kiley B.; Williams, Allison N.; Shaibi, Gabriel Q.
Titel	Response Heterogeneity to Lifestyle Intervention among Latino Adolescents
Quelle	21 (2020), S.1430-1436 (7 Seiten)Infoseite zur Zeitschrift PDF als Volltext (1); PDF als Volltext kostenfreie Datei (2) Verfügbarkeit
Zusatzinformation	ORCID (Peña, Armando) ORCID (Olson, Micah L.) ORCID (Shaibi, Gabriel Q.) Weitere Informationen
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
Schlagwörter	Life Style; Intervention; Hispanic Americans; Adolescents; Obesity; Symptoms (Individual Disorders); Program Effectiveness; Individual Needs; At Risk Persons; Physical Activities; Nutrition Instruction; Health Education; Health Behavior; Skill Development; Diabetes; Prevention + Suchen Sie Ihr Suchwort? Lebensstil; Hispanic; Hispanoamerikaner; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher; Adipositas; Psychiatrische Symptomatik; Risikogruppe; Nutrition education; Ernährungserziehung; Gesundheitsaufklärung; Gesundheitsbildung; Gesundheitserziehung; Health behaviour; Gesundheitsverhalten; Kompetenzentwicklung; Qualifikationsentwicklung; Prävention; Vorbeugung
Abstract	Objective: To characterize the heterogeneity in response to lifestyle intervention among Latino adolescents with obesity. Methods: We conducted secondary data analysis of 90 Latino adolescents (age 15.4 ± 0.9 y, female 56.7%) with obesity (BMI% 98.1 ± 1.5%) that were enrolled in a 3 month lifestyle intervention and were followed for a year. Covariance pattern mixture models identified response phenotypes defined by changes in insulin sensitivity as measured using a 2 hour oral glucose tolerance test. Baseline characteristics were compared across response phenotypes using one-way ANOVA and chi-square test. Results: Three distinct response phenotypes (PH1, PH2, PH3) were identified. PH1 exhibited the most robust response defined by the greatest increase in insulin sensitivity over time ([beta] ± SE, linear 0.52 ± 0.17, P < 0.001; quadratic -0.03 ± 0.01, P = 0.001). PH2 showed non-significant changes, while PH3 demonstrated modest short-term increases in insulin sensitivity which were not sustained over time (linear 0.08 ± 0.03, P = 0.002; quadratic -0.01 ± 0.002, P = 0.003). At baseline, PH3 (1.1 ± 0.4) was the most insulin resistant phenotype and exhibited the highest BMI% (98.5 ± 1.1%), 2 hours glucose concentrations (144.0 ± 27.5 mg/dL), and lowest beta-cell function as estimated by the oral disposition index (4.5 ± 2.8). Conclusion: Response to lifestyle intervention varies among Latino youth with obesity and suggests that precision approaches are warranted to meet the prevention needs of high risk youth. (As Provided).
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01